New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.
نویسندگان
چکیده
Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.
منابع مشابه
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 11 شماره
صفحات -
تاریخ انتشار 2005